Subsequent genetics-focused research has linked C2CD4B to glucose homeostasis, with increased activity promoting the development of type 2 diabetes mellitus by mechanisms that may be sexually dimorphic [29,30,31], and to regulation of coagulation factor VII and von Willebrand factor, with a potential causal role in vascular occlusive disease [32]. The gene discussed is VWF; the disease is type 2 diabetes mellitus.