The loss of mitochondrial transcription factor B1 (TFB1M) leads to mitochondrial dysfunction and T2DM pathogenesis [91], as does the ribosomal RNA (rRNA) methyltransferase homolog of TFB1M, namely dimethyladenosine transferase 1 homolog (DIMT1) [92]. This evidence concerns the gene TFB1M and type 2 diabetes mellitus.