INS and type 1 diabetes mellitus: Circadian dysregulation is also intimately linked to a diverse array of T1DM symptomatology [59], including nocturnal non-dipping blood pressure increasing kidney disease [60], cardiac autonomic neuropathy [61], platelet morphology [62], microvascular complications [63], and patterned immune activity [64], whilst circadian variation in basal insulin requirement can be an early marker of autoimmune polyendocrine syndromes in T1DM [65].