Based on evidence from the two major clinical trials on PCSK9 inhibitors, the FOURIER [104] and the ODYSSEY [106] outcome trials that used evolocumab and alirocumab, respectively, as fully humanized monoclonal antibodies against PCSK9, a recent paper by Gallego-Colon et al. underlines that the 2019 European Society of Cardiology/European Atherosclerosis Society guidelines for the management of dyslipidemias establish the use of PCSK9 inhibitors to very high-risk atherosclerotic cardiovascular disease patients who are unresponsive to a maximum tolerated dose of statins and ezetimibe [107]. Here, PCSK9 is linked to metabolic syndrome.