IKZF1 and acute myeloid leukemia: Interestingly, IKZF1 variants were absent in the fusion gene-positive AML cohort reported by Zhang et al. Analysis of the frequency of IKZF1 variants in three independent studies has evidenced that IKAROSN195S can be considered a hotspot variant in AML, which could be defined as one independent subtype that remains to be investigated [173,174].