INS and Cerebral ischemia: Since the survival and growth of oligodendrocytes and the maintenance of the myelin sheath in the infarcted area largely depend on the activation of the transcription factor CREB, which is one of the targets of insulin [219,220], INI-mediated stimulation of CREB in oligodendrocytes can lead to the restoration of the functions of the white matter, impaired during cerebral ischemia.