In 2014, Chinese scientists found that the treatment of transgenic 3xTg-AD mice predisposed to AD with INI (1.75 IU/day) for 7 days prevents hyperphosphorylation of the tau protein and the triggering of neurodegenerative changes in the brain caused by anesthesia with propofol (i.p., 250 mg/kg) [328]. Here, MAPT is linked to Alzheimer disease.