INS and type 1 diabetes mellitus: Along with T1DM, the combination of INI and ICP was also effective in insulin-deficient “neonatal” model of T2DM, and in this case, along with an improvement in metabolic parameters, a partial restoration of the sensitivity of the adenylate cyclase signaling system to hormonal regulation in the hypothalamus, myocardium, and adipose tissue was shown [207].