Then, through multiple stepwise Cox regression analyses, the prognosis-related risk score for PC patients was calculated with the following formula:Risk score = (−3.2163) × AMT + (0.1613) × ITGA3 + (0.2622) × CDK1 + (0.3034) × IFIT3 + (−0.1363) × CNPY2 + (0.0357) × ANXA1 + (0.3008) × ANKRD22 + (0.1511) × ANXA2 + (−0.1393) × OAS1 + (0.5654) × STYXL1 + (0.0731) × HKDC1 + (0.0311) × LACTB. This evidence concerns the gene ANKRD22 and pachyonychia congenita.