The level of chemical mediators, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and calprotectin, in peri-implant crevicular fluid (PICF) correlates with the progression of peri-implantitis and its usefulness as a biomarker of peri-implant disease is becoming clear [16,17]. This evidence concerns the gene IL1B and Peri-Implantitis.