In vitro and in vivo studies of Tecomella undulata ethyl acetate extract revealed anti-obesity efficacy by downregulating adipogenesis and lipogenesis via sirtuin 1 (SIRT1), adiponectin, and peroxisome proliferator activated receptor γ (PPARγ) [16]. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.