Thus, markers for ER stress (Grp78 and CHOP) and oxidative stress (ROS and MDA levels) were studied, along with ERK1/2, and we found that treatment with Tecomella undulata reduced oxidative stress and ER stress in NASH mice, providing a rationale for low cholesterol and lipid reduction in the liver. Here, HSPA5 is linked to metabolic dysfunction-associated steatohepatitis.