MHLA-DR expression is inversely correlated with surrogate biochemical markers of severity (C-reactive protein [CRP], TNF-α, and IL-6) [127,128,154,155,156,157], clinical scoring systems (Ranson, Acute Physiology and Chronic Health Evaluation II [APACHE II], and MODS criteria) [128,154,157,158], and actual severity of AP [125,127,128,150,151,156,158,159,160], and AP patients with low mHLA-DR expression had approximately 2.7 times longer ICU stays than those with normal expression [159]. The gene discussed is IL6; the disease is alkaline phosphatase measurement.