MMP2 and nervous system disorder: Besides their role in the neurological disorders, MMPs might contribute to the development of cardiovascular diseases and diabetes mellitus, increasing the all-cause mortality [34]: higher plasma levels of MMPs (MMP2 and 10) have been observed in patients with type 1 diabetes [35,36], associated with log-grade inflammation and endothelial dysfunction (MMP2 and MMP9) [37,38] and renal disorders (MMP9) [39].