For example, upon VEGF binding to VEGFR2 expressed on their membrane, TAMs polarize to an M2-like phenotype [103,104] and secrete angiogenic and immunosuppressive cytokines (e.g., IL-10, TGFβ, and VEGF) that favor tumor progression [105,106,107]. This evidence concerns the gene TGFB1 and neoplasm.