ANGPT2 and breast cancer: In addition, the dual blockade of angiopoietin-2 and VEGF-A by a bispecific antibody (A2V) causes the normalization or regression of tumor vessels, the extravasation and perivascular accumulation of activated CD8+ cytotoxic T lymphocytes, the necrosis of BC, and, consequently, the presentation of neoantigens by intratumor phagocytes [132].