In this regard, in vitro experiments have shown that BC-derived cell lines secrete VEGF, which, in turn, inhibits the differentiation, maturation, and function of DCs from the healthy donor, and that VEGF gene silencing is followed by an increase in the expression of activation markers such as CD80, CD83, CD86, and HLA-DR on the DC’s surface [89]. The gene discussed is VEGFA; the disease is breast cancer.