Considering the molecular features of FH, the ClinGen Familial Hypercholesterolemia Variant Curation Expert Panel created specific guidelines for variants in the LDLR gene [89] and applied them to several variants that are now reported in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar/ accessed on 29 December 2022) as “Reviewed by expert panel” (https://www.ncbi.nlm.nih.gov/clinvar/submitters/508055/ accessed on 29 December 2022). This evidence concerns the gene LDLR and familial hypercholesterolemia.