LDLRAP1 and familial hyperaldosteronism: Oligogenic FH was first defined in 2018 as the contemporary presence of a heterozygous variant in one of the FH-causative genes and of a heterozygous variant in genes causing recessive hypercholesterolemia (LDLRAP1), sitosterolemia (ABCG5 and ABCG8) or APOE [66].