There are also reports showing that USP4, 7, 10, 18, and 22 attenuate NAFLD progression [98,108,110,113,194,198], whereas other reports have indicated that USP2, 7, 11, 14, 19, 20, and 22 exacerbate NAFLD [49,99,107,187,188,196,201,202,204,207]. Here, USP4 is linked to metabolic dysfunction-associated steatotic liver disease.