Furthermore, 14a–c exhibited cell growth percents below −90 in some cell lines belonging to NSCL, colon, CNS, ovarian, renal, and breast cancer, and even caused more sound lethal effects towards some cell lines with growth percent −100, including NCI-H322M (NSCL cancer), HCT-15 (colon cancer), SF-539, SNB-19 (CNS cancer), LOX IMVI, MDA-MB-435, SK-MEL-28, SK-MEL-5 (melanoma), OVCAR-5 (ovarian cancer), ACHN and CAKI-1 (renal cancer). The gene discussed is LOX; the disease is central nervous system cancer.