Concisely, APS is characterized by persistent positivity for antiphospholipid antibodies [aPL, including lupus anticoagulant (LA), anticardiolipin (aCL) and anti-β2-glycoprotein1 antibodies (anti-β 2GPI)], thrombotic events and/or severe pregnancy morbidity [1,2,3,4]. The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.