Interestingly, transgenic AD mice actively immunized with NGFR/p75NTR ECD showed a lower level of NGFR/p75NTR ECD and a more severe AD pathology in the brain and worse cognitive functions compared to two different control groups immunized with the reverse sequence of NGFR/p75NTR ECD and phosphate-buffered saline, respectively. The gene discussed is NGFR; the disease is Alzheimer disease.