Given the multiple functions and implications of NGFR/p75NTR in the central nervous system (CNS), this review will explore the genetic and molecular evidence surrounding its relationship with AD, the experimental evidence around NGFR/p75NTR-driven AD neuropathology, as well as the relevance of this protein as a prognostic–diagnostic tool and therapeutic target for AD. Here, NGFR is linked to Alzheimer disease.