Interestingly, by analyzing another cohort (279 cognitive normal, 480 MCI, and 47 AD) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database it has also been shown that T allele at the rs2072446 variant was also associated with the heavier Aβ burden, which further contributed to an increased risk of AD progression in APOE ε4 non-carrier. Here, APOE is linked to Alzheimer disease.