The authors analyzed the genetic variability of four functional NGFR/p75NTR polymorphisms (i.e., rs2072445 and rs2072446 located in exon 4, rs741072 located in exon 6, rs734194 located in the 3′-UTR) and the risk of developing AD in an Italian sample consisting of 151 sAD patients, 100 fAD patients, and 97 healthy subjects. The gene discussed is NGFR; the disease is Alzheimer disease.