Consistently with the results for HEK293T cells, depletion of DDX6 also significantly increased the A-to-I editing levels caused by ADAR1p110 and ADAR2 in SH-SY5Y cells (Figure 6C), suggesting that DDX6 also exhibits a repressive function in regulating ADAR activity in neuroblastoma cells and could be ubiquitous in various human cell types. This evidence concerns the gene DDX6 and neuroblastoma.