The bottom row of Figure 4 demonstrates that three markers of PGE2 signaling are upregulated in the HSP/neutrophil/PGE2 tumor group—neutrophilic aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), stromal/T-cell growth arrest and DNA-damage-inducible protein GADD45 alpha (GADD45A), and astrocytic CEBPD. This evidence concerns the gene BMAL1 and neoplasm.