In conclusion, based upon the likely X-linked recessive inheritance, the later and milder clinical muscle manifestations, the persistently high serum CK activities, the histopathological muscular dystrophy, and a single DMD missense variant, we believe this family represents the first clinical-to-molecular genetic characterization of a Becker type and thus cross-reactive material positive (CRM+) dystrophin deficiency in cats. The gene discussed is DMD; the disease is muscular dystrophy.