Our results indicated that all up-regulated (NCAPG, MKI67, CCNA2, CCNB1, TPX2) and down-regulated (CDK1, CCNB2, AURKA, UBE2C, BUB1B, CENPF, RRM2) genes were expressed significantly higher in PCa tissues compared with normal prostate tissues. This evidence concerns the gene TPX2 and posterior cortical atrophy.