RRM2 and posterior cortical atrophy: TFs such as AR, TWIST1, FOXA1, SOX9, E2F, and ASCL1 [28], or TATA, CEBPB, E2F, SRY, and NFKAPPAB [27], and modulators such as BUB1B, TOP2A, UBE2C, RRM2, and CENPF [28] have been indicated to be directly involved in biological processes creating numerous phenotypic modifications, proliferation, and differentiation in PCa progression.