Our results indicated that all up-regulated (NCAPG, MKI67, CCNA2, CCNB1, TPX2) and down-regulated (CDK1, CCNB2, AURKA, UBE2C, BUB1B, CENPF, RRM2) genes were expressed significantly higher in PCa tissues compared with normal prostate tissues. The gene discussed is MKI67; the disease is posterior cortical atrophy.