The results indicated for box whisker plots that all hub genes (up-regulated: NCAPG, MKI67, CCNA2, CCNB1, TPX2; and down-regulated: CDK1, CCNB2, AURKA, UBE2C, BUB1B, CENPF, RRM) were significantly changed in PCa tissues (p-value < 0.001) compared with the normal prostate tissues (Figure S1). This evidence concerns the gene CENPF and posterior cortical atrophy.