TPX2 and posterior cortical atrophy: It was also observed that hub genes (up-regulated: NCAPG, MKI67, CCNA2, CCNB1, TPX2; and down-regulated: CDK1, CCNB2, AURKA, UBE2C, BUB1B, CENPF, RRM) were significantly altered in PCa samples based on patients’ age (41–60 years and 60–80 years) (p-value < 0.05) compared with normal prostate tissues (Figure S2).