The Venn diagram (Figure 11) shows CTD analyses of chemicals that were associated with 5 up-regulated hub genes (NCAPG, MKI67, TPX2, CCNA2, CCNB1) and 7 down-regulated hub genes (CDK1, CCNB2, AURKA, UBE2C, BUB1B, CENPF, RRM2) associated with PCa in the CTD curated studies. The gene discussed is AURKA; the disease is posterior cortical atrophy.