All hub genes (up-regulated: NCAPG, MKI67, TPX2, CCNA2, CCNB1; and down-regulated: CDK1, CCNB2, AURKA, UBE2C, BUB1B, CENPF, RRM2) affected the survival of the PCa patients with high Gleason scores (Figure 10). Here, CCNB2 is linked to posterior cortical atrophy.