HLTF and amyotrophic lateral sclerosis: For instance, circSLC8A1 shows four binding sites for miR-335-3p and three for miR-27a-3p, miR-27b-3p and miR-30d-3p, and the mRNA targets of these miRNAs are involved in processes that are altered in ALS such as: neuroprotection (e.g., ADAM12 [64]), DNA damage repair (e.g., HLTF [65,66]), protein trafficking regulation and axonal guidance/elongation (e.g., SNX18 and DPYSL3 [67,68]), splicing regulation (e.g., EXOC7 and FUBP1 [69,70]), neuronal excitability and synaptic transmission (e.g., NEDD4L [71]).