Previous studies have uncovered the genomic landscape of CLL and identified several genes carrying mutations at ˃5% frequency, such as TP53 (5–15%), ATM (9–15%), MYD88 (2–13%), SF3B1 (8–21%), and NOTCH1 (4–13%) [6,13,16,17,18,37,38]. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.