CD4 and systemic lupus erythematosus: A reduced expression and activity of DNMTs are related to hypomethylation and active demethylation mediated by ten-eleven translocation proteins (TETs), which could influence changes in DNA methylation and alter the expression of genes involved in the immune response; in this sense, it was previously reported that hypomethylation of IFN-related genes such as IFI44L and BST2 correlated with overexpression of these genes in total CD4+ T cells from lupus patients [13].