In SLE, pyridoxine has been inversely associated with atherosclerotic plaque, a common alteration in these patients; there is no evidence of pyridoxine and DNA methylation in SLE; however, an adequate intake of this vitamin may reduce cardiovascular alterations in SLE and avoid disturbances of the MTHFR activity [49,50]. This evidence concerns the gene MTHFR and systemic lupus erythematosus.