F5 and obesity due to melanocortin 4 receptor deficiency: Olié et al. found that risk factors for VTE recurrence may differ between male and female: Factor V Leiden mutation was a risk factor for recurrent VTE in male patients (HR 3.5, 95%CI, 1.5–8.1), while in women, the VTE recurrence rate seems to be more related to age at first event (HR 1.3, 95%CI, 1.1–1.5) and obesity (HR 2.5, 95%CI, 1.1–5.5) [44].