For example, NOB, A1541, A1543, KCR and securinine can effectively promote the differentiation of dual potent progenitors and erythroid progenitors into megakaryocytes, such as HEL cells and K562 cells, and effectively alleviate the abnormal increase in erythroid cells in leukemia patients by inhibiting their cycle arrest. The gene discussed is CLEC4F; the disease is leukemia.