PAA may share TAAD predisposing genes mutations interesting the transforming growth factor beta (TGFβ) signal, extracellular matrix (FBN1, TGFBR1, TGFBR2, SMAD3, TGFB2, COL3A1), and altered components of the contractile apparatus of the smooth muscle cells (SMC): ACTA2, MYH11, MYLK, and PRKG1 [4,29]. This evidence concerns the gene FBN1 and pulmonary artery-aorta diameter ratio measurement.