Co-occurrence of FLT3-ITD and/or DNMT3A mutation is found in approximately 66% of NPM1-mutated AML, which portends an inferior prognosis [79,80,81,82,83], constituting an indication for allogeneic haematopoietic stem cell transplantation (HSCT) in eligible patients. Here, DNMT3A is linked to acute myeloid leukemia.