Regarding AFP-negative HCC cases, hsa-miR-21-5p/hsa-miR-199a-5p and has-miR-155-5p/hsa-miR-199a-5p ratios can be used to better identify HCC development in LC patients with CHCV-G4 infection, with higher sensitivities. This evidence concerns the gene AFP and hepatocellular carcinoma.