According to Liu et al. [29], hsa-miR-199a-5p downregulation plays a crucial role in the growth and the development of HCC, and they added that the protective role of hsa-miR-199a-5p is played through its ability to inhibit HCC cell migration and invasion by targeting the metastasis promoter MAP4K3. This evidence concerns the gene MAP4K3 and hepatocellular carcinoma.