According to Kim, et al. [53], oxyresveratrol and mulberroside A showed almost the same inhibition of cellular tyrosinase and melanin synthesis, but oxyresveratrol showed stronger inhibition of mushroom tyrosinase than mulberroside A. Similarly, Ochaiai et al. (2016) demonstrated two peptides that significantly inhibit the mushroom tyrosinase but did not inhibit melanin production in melanoma cells, suggesting they do not inhibit the mammalian tyrosinase [10]. Here, TYR is linked to melanoma.