After performing a pan-cancer overall survival analysis by GEPIA2, we observed that the high expression of ZNF385A was associated with poor prognosis in HNSC, KIRC, LAML, LIHC, THYM (Thymoma), and UVM (Uveal Melanoma), and a high expression of ZNF346 was correlated with a poorer OS only in LIHC; therefore, we then focused on the analysis of ZNF385A and ZNF346 on LIHC (Figure S1). This evidence concerns the gene ZNF385A and cancer.