KDR and Patent ductus arteriosus: Our in vitro study showed that PDA promotes high expression of NRP1, activates the VEGF signaling pathway, accelerates the recruitment of VE-Cad through the interaction of NRP1 with VEGFR2 and, ultimately, promotes the proliferation and migration of umbilical vein endothelial cells, which facilitates the repair of the endothelial barrier and inhibits pathological vascular remodeling.