Furthermore, compared with non-heart failure, i.e., the expression of MMP-2, Col1a1, Col3a1, N-Cadherin and PTGS2 was significantly higher (p < 0.01), and the expression of SERCA2 (p < 0.05) was significantly lower, and the expression of MMP-9, E-Cadherin, β-Catenin, CnA and RyR was unchanged in ischemic heart failure (Figure 7F). This evidence concerns the gene RYR2 and heart failure.