Inclusively, the expression patterns of the most proteins (MMP-2, Col1a1, Col3a1, N-Cadherin, β-Catenin, CnA, RyR, SERCA2 and PTGS2) in human heart failure are consistent with the discoveries above in the Cre recombinase-induced cardiotoxicity model. Here, MMP2 is linked to heart failure.