RYR2 and cardiomyopathy: From the physiological perspective, the phenomenon may suggest that the hormone has no effect on the cardiomyopathy caused by Cre recombinase, which may be involved in the non-ryanodine receptor-associated calcium pathway because, in our case, ryanodine receptor was not regulated based on the amount of alternation of the RyR in Cre mice (Figure 6E,F).