Receptor-interacting serine-threonine kinase (RIPK1) and RIPK3 play important roles in necroptosis, and Deutsch et al. found that in APAP mediated ALI, RIPK3 deletion or specifically blocking RIPK1 using Necrostatin-1 (Nec-1), an inhibitor of RIPK1, was protective against liver injury and associated with inhibition of NLRP3 inflammasome activation [128]. Here, NLRP3 is linked to acute respiratory distress syndrome.