However, this article mainly summarizes the interaction of NLRP3 inflammasome with apoptosis, necroptosis, pyroptosis, as well as autophagy, in ALI (Figure 3) and does not involve iron death in ALI, whether NLRP3 inflammasome can interact with ferroptosis and thereby participate in the pathogenesis of ALI needs to be further clarified and studied. The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.