A study including three amyotrophic lateral sclerosis (ALS) male patients (average age 42 ± 3.06 years) and three healthy male controls (average age 39.33 ± 3.79 years) demonstrated that the level of plasma exosomal coronin-1a (CORO1A) of ALS patients was 5.3 times higher in the ALS patients than that of healthy controls. The gene discussed is CORO1A; the disease is amyotrophic lateral sclerosis.