HAND2 and adenomyosis: In general, upregulation of inflammation-, angiogenesis-, and fibrosis-related molecules and downregulation of decidualization-related molecules (e.g., PRL, IGFBP1, HOXA10, FOXO1, CEBPB, IHH, bone morphogenetic protein 2 (BMP2), nuclear receptor subfamily 2 group F member 2 (NR2F2), Wnt family member 4 (WNT4), and HAND2) are hallmarks of adenomyosis [5,14,94].