When cut-offs of plasma IL-37 levels were considered with respect to their practical utility in identifying some specific subgroups of older diabetic patients, the best results were obtained in terms of negative prediction (exclusion) (NPV) of patients with low renal function (GFR < 45 mL/min) and those who have experienced CAD, and for positive prediction (recognition) (PPV) of those with low body mass (BMI < 25 kg/m2), those with diabetic retinopathy, and those who are characterized with comorbidities (>3). Here, IL37 is linked to coronary artery disorder.