It is worth noting that cytokine regulation, and in particular regarding IL-37, as a negative regulator of inflammation is generally more complex in multifactorial age-related conditions (such as type 2 diabetes (T2D), where patients with the same diagnostic label share multiple pathophysiology pathways and exhibit heterogeneous clinical expression), than in autoimmune and immunologically mediated diseases, which are characterized by high-impact genetic and environmental exposures, and which are more homogeneous in phenotypic expression [19,20]. This evidence concerns the gene IL37 and type 2 diabetes mellitus.