However, our study has several strengths, including the well-characterized population that we have studied, as well as the homogenous methylation analysis for all the samples, quality control and the use of the 850 K array instead of the 450 K. In addition, we conducted functional enrichment analyses of the differentially methylated CpGs and found strong associations with pathways associated with various cancers, inflammation, insulin metabolism, and cardiovascular diseases, in accordance with previous studies [61,106]. Here, INS is linked to cancer.