The aim of this study was to assess the impact of Pb exposure on DNA oxidative damage, as well as the modulation of hemochromatosis (HFE) polymorphisms on Pb body burden, and the toxicity of Pb, through the analysis of 8-hydroxy-2′-deoxyguanosine (8-OHdG), in subjects occupationally exposed to the metal. Here, HFE is linked to hemochromatosis type 1.