A significantly higher (p < 0.05) concentration of HEX activity after the conversion to kg of creatinine (μKat/kgCr) was found in the urine of men with alcohol-dependence without neoglandin treatment, as compared to those taking neoglandin on days 1, 4, and 7 of treatment (Table 3 and Figure 9). The gene discussed is HHEX; the disease is alcohol dependence.