Purrington et al. evaluated ER staining levels in a cohort of 1573 women from Detroit, MI, classifying ER staining levels as weak (1–10% staining), moderate (11–50% staining) or strong (>50%) and found that Black women were significantly more likely to have both weakly staining (odds ratio (OR) 2.19, 95% CI 1.14–4.23) and moderately staining (OR 2.80, 95% CI 1.37–5.71) breast tumors comped to White women [25]. The gene discussed is ESR1; the disease is breast neoplasm.