The decrease in all PON1 activities has been shown to range between about 20 and 80% in various types of cancer (e.g., lung, breast, prostate, gastrointestinal, central nervous system tumors and several types of lymphomas), where the loss of antioxidant protection is manifested in increased amounts of hydroperoxides, ox-LDL, malondialdehyde and conjugated dienes [71]. The gene discussed is PON1; the disease is cancer.