Subgroups CLL#3, CLL#5, CLL#6, and CLL#7H are significantly enriched with SF3B1 gene mutations, which are often observed in combination with unfavorable chromosomal aberration del 11q, and associated with an insufficient response to immunochemotherapy and poor prognosis [48,49]. This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.