Besides CLL#3, CLL#5, CLL#6, and CLL#7H, subgroups are based on the IGHV1-69 gene, and the frequency of SF3B1 gene mutations is twice as high in CLL#5 and CLL#3 subgroups comparing to CLL#6 subgroup (38–40% vs. 20%). The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.