In a study within Eurasia made up of Caucasians (Study group n = 873) from Russia and Germany, Central Asian Mongolians, and Arctic Mongolians, rs1293762 (OAS-2; T > G), (Figure 2) was linked to disease outcome in patients with TBE, while an increase in the frequency of the “A” allele of rs15895 (OAS-2; A > G) was found to be significantly higher in severe TBE patients [71]. This evidence concerns the gene OAS2 and tick-borne encephalitis.