In 2003, Goossens et al. reported that various homozygous or heterozygous mutations in DSEL, such as p.Val287Ile, p.Pro673Ser, p.Tyr730Cys, p.Pro942Ser, p.Ile1113Met, and a substitution of adenine to guanine in the 5′-non-coding region 546 bp upstream of the coding region, caused bipolar disorder [92]. The gene discussed is DSEL; the disease is bipolar disorder.