Proband 5, a female subject affected by TS, speech disorder, and EEG abnormalities, had a partial duplication of the short arm of chromosome 4p14 of about 2.7 Mb, encompassing about 30 genes, including TLR1 (MIM:601,194), WDR19 (MIM:608,151), RFC1 (MIM:102,579), LIAS (MIM:607,031), UGDH (MIM:603,370), and RHOH (MIM:602,037). The gene discussed is UGDH; the disease is speech disorder.