In addition, GATA6, DEAD box RNA helicase protein DDX1, Jade family PHD finger 3 (JADE3) have been implicated as direct activators of LGR5 expression, while Dickkopf-2 (DKK2) indirectly activates LGR5 expression by promoting downstream degradation of hepatocyte nuclear factor 4-α (HNF4ɑ1) in CRC [38,39,40,41,42]. Here, JADE3 is linked to colorectal carcinoma.