In addition, there are two subpopulations of neutrophils: (i) N2 that promotes tumor progression via release of the aforementioned molecules, and (ii) N1 that restricts immunosuppression via release of intercellular adhesion molecule 1(ICAM-1), tumor necrosis factor-α(TNF-a), as well as production of reactive oxygen species(ROS) [13]. The gene discussed is TNF; the disease is neoplasm.