In this study, upon assessing the individual susceptibility to the development of NSCLC, we may observe relevant results with respect to the polymorphisms of NFKB1 (rs28362491), PAR1 (rs11267092), and TP53 (rs17878362), all three of which are associated with the reduction in the risk of developing NSCLC, whereas the polymorphisms of IL-1A (rs3783553) and UCP2 (INDEL 45-bp) are associated with a higher risk of developing that neoplasm. The gene discussed is TP53; the disease is neoplasm.