The genotypes of the polymorphisms of NFKB1 (rs28362491), PAR1 (rs11267092), and TP53 (rs17878362) were associated with a lower risk for disease development, and the genotypes of the polymorphisms of IL-1A (rs3783553) and UCP2 (INDEL 45-bp) were associated with a growth in the susceptibility to that malignant neoplasm. This evidence concerns the gene NFKB1 and cancer.