The analysis of the genotype and allele distribution revealed that the polymorphisms NFKB1 (rs28362491), PAR1 (rs11267092), and TP53 (rs17878362) presented variations associated with those at the lowest risk for the development of NSCLC, whereas the variations of the polymorphisms of gene IL-1A (rs3783553) and UCP2 (INDEL 45-bp) were associated with the risk of developing the disease (Table 4). This evidence concerns the gene IL1A and non-small cell lung carcinoma.