The aim of this study was to evaluate the association between the IL-1A (rs3783553), NFKB1 (rs28362491), TP53 (rs17878362), PAR1 (rs11267092), and UCP2 (INDEL 45-bp) susceptibilities to NSCLC in the Brazilian Amazon. Here, TP53 is linked to non-small cell lung carcinoma.