The results from large genome initiatives collecting data from stroke patients worldwide highlight potential candidates, such as an intronic variant of a gene encoding PPP1R21, a regulatory subunit of protein phosphatase-1 [5], apolipoprotein E (APOE), and brain-derived neurotrophic factor (BDNF), to be involved in brain plasticity and strongly related to the functional outcome [6]. The gene discussed is APOE; the disease is stroke disorder.