Further research is needed to confirm whether the low expression or absence of connexin and pannexin-1 in undifferentiated LSCC, which have the worst prognosis, is a consequence or cause of the pathophysiological cascade, and why they exhibit opposite biological behavior in different tumors or even in different cell lines of the same tumor type, as reported in gliomas [9]. Here, PANX1 is linked to neoplasm.